Must be a current smoker. Must be 30 days clear from last participation to prior to product administration. Surgically sterile females must have documentation at screening. BRING A PACK OF YOUR USUAL BRAND CIGARETTES TO YOUR APPT. Face masks required.

Age 18-85. No BMI requirement. Must be 90 days clear from last participation to screening. Smokers allowed - no smoking at unit. GFR must be higher than 60.

Must bring start and end dates of last 4 cycles to screening. Bring normal PAP results from w/in the last 3 years if available. If 40 or older bring last mammogram records if done within the last year if able. No hormonal birth control. Multiple payments.

Clearance 3 months participation to dosing, No if gallbladder removed, GFR must be 90 or higher, Surgically sterile females must bring documentation, non smokers. If you DNQed for the SAD portion of this study, you CANNOT screen for this study.

Part A age 18-49 , Clearance 1 month last dose to prior to enrollment, no previous exposure to COVID, 8 hr fast. Smokers allowed.

Age 18-45. Compensation in 2 payments. Must be 30 days clear from last dose to PRIOR to screening. Surgically sterile females must bring documentation to screening. Face masks are required. Abstinence is NOT an option for this study.

Must be 28 days clear from last dose to prior to dosing. Must have good veins. SMOKERS ALLOWED. Please review study length/dates on the website to be sure you can do them.

Must be diagnosed with ADPKD, age 18-70, must not have done another study with 28 days of dosing, no tattoos, scarring or other conditions on the abdomen. NOTE: please bring all medications with you. Fasting not recommended or required.

No smokers. Must be 30 days clear from last dose or device PRIOR to screening. 8 hour fast. Surgically sterile females must bring docs.