If surgically sterile, must bring documents. Study includes a spinal tap. If you had spinal surgery or herniated disk, you do not qualify.

Must have good veins in BOTH arms. Must be 30 days clear from last dose to prior to 1st dose. No smokers. If surgically sterile, must bring documentation.

Must be 30 days clear from last dose to prior to 1st dose. No smokers. If surgically sterile, must bring documentation to screening.

2 part screening. 1st visit- sign consent (no fasting), 2nd visit- procedures. Must be 30 days clear from last participation to prior to screening. If surgically sterile, MUST bring documentation. No out-of-state subjects. No smokers

Not currently screening males. MALES WILL BE CANCELLED. Appts are for non-menthol FEMALE smokers only. YOU MUST BRING A PACK OF YOUR USUAL BRAND OF CIGARETTES TO YOUR SCREENING APPT. 12 hour fast. If surgically sterile, bring documentation if possible.

Study includes a spinal tap. Eye exam done offsite. Females must be postmenopausal or surgically sterile with documentation at screening. 30 days from last participation to prior to dose. No smokers. Willing to consume standardized meals.