30 days from last participation in a study to prior to screening for this study.

8 hour fast, 30 days or 5 half-lives from last dose in a study to prior to first dose for this study, surgically sterile females must bring documentation, GFR greater than 90

Age 18-45. Clearance 30 days participation to screening

Must bring start and end dates of last 4 cycles to screening. Bring normal PAP results from w/in the last 3 years if available. If 40 or older bring last mammogram records if done within the last year if able. No hormonal birth control. Multiple payments.

Healthy adults $9,000 - Not participated in a clinical study of a drug or device within 30 days or a study involving a biologic in the last 3 months prior to dosing. Surgically sterile females must bring documentation. No if gallbladder removed.

$6,000. Age 18-50. Clearance 30 days participation to dose. GFR is greater than 90. Multiple payments.

Must be 30 days last participation to prior to dose, 8 hr fast

Compensation in 2 payments. Must be 30 days clear from last dose to PRIOR to screening. Surgically sterile females must bring documentation to screening. Abstinence is NOT an option for this study.

Must be 28 days clear from last dose to prior to dosing. Must have good veins. SMOKERS ALLOWED. Please review study length/dates on the website to be sure you can do them.

PRE- SCREENING for adults with nonalcoholic fatty liver disease only or those with risk factors. THIS IS NOT THE SCREENING FOR THE ACTUAL STUDY. Insulin resistant and Type 2 Diabetics allowed. No smokers. Call 210-225-5437 to see if you qualify.

Must be diagnosed with ADPKD, age 18-70, must not have done another study with 28 days of dosing, no tattoos, scarring or other conditions on the abdomen. NOTE: please bring all medications with you. Fasting not recommended or required.

Clearance time is 5 half lives since last dosing to prior to this dosing. Surgically sterile females must bring documentation. No smokers. *Note Cohort 1 participants must weigh between 187 and 220 pounds.